From.Dr.junko

2018年10月23日
American College of Rheumatology -Antinuclear antibodies Mark H. Wener

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2018年10月23日
Novel SLE treatment-pipeline of portential new therapies

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2018年10月23日
Novel SLE treatment-Belimumab

Belimumab
・new phase 3
・Subcutaneous-BLISS -SC
・Long term Safety IV Belimumab
・Lupus Nephritis
・pediatric- Phase 2 PLUTO

2018年10月23日
Novel SLE treatment-immunosuppressive therapy

summary of evidence
Cyclophosphamide(IVCY)
・Effective in inducing renal remission and preventing renal failure.
・Improves survival
・Low dose(Euro-dosing)is as effective and appears to have less toxicity.
MMF
・evidence of effectiveness
・Effective as maintenance after both IVCY and MMF induction
・Appears to have less toxicity than IVCY
Tacrolimus(TAC)
・as effective as IVCY in menbranous GN
・Significantly higher rate of renal relapse after completion of 1 yr treatment






















2018年10月23日
Novel SLE treatmentーHydroxy chloroquine

Beyond disease activity~Multiethnic longitudinal cohort (n=635)~
reduced damage accrual
decrease in renal damage
decrease in skin-damage
decrease in vascular events.
Anti-malarial toxicity
Rertina-weight based dosing:Toxicity near 1% after 5-7years:Cumulative dose of 1000g :Baseline then annual after 5 yrs.
Skin-Hyperpigmentation
Muscle-Curvilinear bodies:muscle fiber atrophy:Vacuolar changes
Toxic-Myocardial Disease:47cases median doses 1050g for CQ and 1542g for HCQ Chronic heart failure.
Excreted by kidney
High risk patients-concomitant tamoxifen(increase risk 5-fold)
GFR<50cc/min, dose>5mg/kg
Risk is <2% up to 10 yrs but rises to 20 % after 20 years.
safe rule is 5x5 Screen after 5 yrs use and <5mg/kg real weight
[picture: a sunday on La Grande Jatte]

2018年10月21日
AmericanCollege of Rheumatology in Chicago

I started checking “Lupus nephritis”.

Here is Dr. Igawa, who worked for us lang time ago and He worked catheterization in Shimonoseki, does the research in Nagasaki Univ. about Lupus nephritis. He investigated the
Cause of Lupus nephritis.

Good Job! Dr. Igawa

2018年10月20日
American College of Rheumatology in Chicago

CHICAGO, CHICAGO!!!
fantastic!!!

Ooops,
We can see "TRUMP TOWER!".
Let's see ......go back to meeting and study!

2018年10月06日
10th anniversary in Kawata-Junko Clinic

Thanks you for 10 years anniversary in Kawata-Junko clinic.
We came lomg way.
Human-being are social creature.
I felt strange power for ten years.

2018年10月06日
lecture ofconnective tissure diseases in Kaiko Messe in Shimonoseki

We had typhoon today.
I did that during the storm.
Thank you for coming.

I talked about Nobel prize winner,Yamaguchi-native DR. Honsyo,
What he had done , and immunology.

We are planing to have it next end of March.
Thanks,

2018年09月21日
Academic meeting for radiological technologists

There are meeting for radiological technologists.
Over 2000 people crowded into the bar and pubs.